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RecruitingPhase 4NCT05892744

Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression

Establishing Multimodal Brain Biomarkers Using Data-driven Analytics for Treatment Selection in Depression

Sponsor

University of Texas at Austin

Enrollment

50 participants

Start Date

Sep 30, 2023

Study Type

INTERVENTIONAL

Conditions

Major Depressive DisorderChronic Major Depression, Recurrent

Summary

The purpose of the study is to identify brain biomarkers and characteristics that predict individual responses to treatment of major depression with the antidepressant drug sertraline (tradename Zoloft), a common selective serotonin reuptake inhibitor (SSRI) antidepressant. Our central hypothesis is that brain activity and connections jointly measured with functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) will be able to predict an individual's response to sertraline treatment.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study uses brain scans and other tests to identify biological markers (biomarkers) in the brain that can help doctors predict which treatments will work best for a given person with depression. **You may be eligible if...** - English is your primary language and you can understand instructions - You meet criteria for a current major depressive episode (diagnosed via a structured clinical interview using DSM-5) **You may NOT be eligible if...** - You are not currently experiencing a major depressive episode - You have cognitive or language difficulties that prevent completing assessments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSertraline

50-200mg/day

Locations(1)

Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600

Austin, Texas, United States

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NCT05892744

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