RecruitingNCT05899439

Immune Function and the Progression to T1D

Immune Function and the Progression to Type 1 Diabetes:

Sponsor

University of Florida

Enrollment

2,800 participants

Start Date

Jan 1, 2005

Study Type

OBSERVATIONAL

Conditions

Type 1 Diabetes

Summary

To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.

Eligibility

Min Age: 0 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study is tracking immune system changes in people who may be at risk for developing Type 1 diabetes, to better understand what happens in the body before and during the development of the disease. **You may be eligible if...** - You are able to have blood drawn **You may NOT be eligible if...** - There are no specific exclusion criteria listed for this study This is a low-burden observational study — primarily involving blood draws. Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERblood draw

a peripheral blood draw

Locations(3)

Kieran McGrail

Gainesville, Florida, United States

The Ohio State University

Columbus, Ohio, United States

Baylor College of Medicine, Center for Research Advancement - Texas Children's Hospital

Houston, Texas, United States

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NCT05899439

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