RecruitingNCT05899621

A Real-world Study of Obinutuzumab-based Therapy for Previously Untreated FL

A Real-world Study of the Efficacy and Safety of Obinutuzumab-based Therapy for Previously Untreated Follicular Lymphoma


Sponsor

Ruijin Hospital

Enrollment

332 participants

Start Date

Jun 1, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

This study aims to observe and explore the efficacy and safety of obinutuzumab-based therapy for previously untreated follicular lymphoma


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This real-world study is tracking how well obinutuzumab-based therapy works for people newly diagnosed with follicular lymphoma (a slow-growing type of blood cancer) in routine clinical practice outside of a controlled trial setting. **You may be eligible if...** - You have been diagnosed with CD20-positive follicular lymphoma, Grade 1, 2, or 3A - You have never received treatment for this lymphoma - You are 18 or older and have measurable disease on a CT or PET scan - Your doctor has decided you need treatment and that obinutuzumab-based therapy is appropriate **You may NOT be eligible if...** - Your follicular lymphoma has transformed to a more aggressive type or is Grade 3B - You are HIV-positive, or have active hepatitis B or C infection - Your lymphoma has spread to the brain or spinal fluid - There are contraindications to the planned treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGObinutuzumab

Obinutuzumab IV infusion will be administered as per the schedule specified in the respective arm.

DRUGLenalidomide

Lenalidomide PO will be administered as per the schedule specified in the respective arm.

DRUGBendamustine

Bendamustine IV infusion will be administered as per the schedule specified in the respective arm.

DRUGCyclophosphamide

Cyclophosphamide IV infusion will be administered as per the schedule specified in the respective arm.

DRUGDoxorubicin

Doxorubicin IV infusion will be administered as per the schedule specified in the respective arm.

DRUGVincristine

Vincristine IV infusion will be administered as per the schedule specified in the respective arm.

DRUGPrednisone

Prednisone PO will be administered as per the schedule specified in the respective arm.


Locations(1)

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, China

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NCT05899621


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