A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

This Phase I/II study is testing VLS-1488, a new oral anticancer drug, in adults with various types of advanced solid tumors that have stopped responding to standard treatments. The study first tests safety at increasing doses, then expands to specific cancer types. **You may be eligible if...** - You are 18 or older with good general health (ECOG ≤1) - You have at least one measurable tumor on CT or MRI - You can swallow oral medication - Your cancer is one of the eligible types, including: high-grade serous ovarian cancer, squamous non-small cell lung cancer, triple-negative breast cancer, gastric adenocarcinoma, colorectal, esophageal, bladder, head and neck squamous cell, or certain endometrial cancers - You have received standard treatments that are no longer working **You may NOT be eligible if...** - You have significant heart, liver, or kidney problems - You have untreated or unstable brain metastases - You are pregnant or breastfeeding - You are taking medications that cannot be safely combined with VLS-1488 Talk to your doctor to see if this trial is right for you.