RecruitingPhase 3NCT05904028

Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD

Sponsor

Jaeb Center for Health Research

Enrollment

600 participants

Start Date

Nov 9, 2023

Study Type

INTERVENTIONAL

Conditions

Neovascular Age-related Macular Degeneration

Summary

Home optical coherence tomography- guided treatment versus treat and extend for the management of neovascular age-related macular degeneration.

Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether people with wet age-related macular degeneration (AMD) — a common cause of vision loss in older adults — can receive eye injections less frequently if they self-monitor their eye health daily using a home scanning device, compared to a standard "treat and extend" injection schedule. **You may be eligible if...** - You are 50 years old or older - You have been recently diagnosed with wet AMD (abnormal blood vessel growth under the retina) that has not yet been treated - You have some vision in the affected eye (roughly 20/320 or better) - You are able to use the home eye-scanning device independently - You can commit to daily scans for 2 years **You may NOT be eligible if...** - You have already received any eye injections or laser treatment for AMD or any other eye condition - You have received steroid injections in the eye in the past 6 months - You have a condition that would prevent you from completing daily scans (such as dementia, Alzheimer's disease, or uncontrollable tremors) - Your AMD is caused by another eye condition (e.g., severe nearsightedness or histoplasmosis) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIntravitreal injections of 6 mg faricimab on a Treat and Extend schedule

Intravitreal injections of 6 mg faricimab on a Treat and Extend schedule

DEVICEIntravitreal injections of 6 mg faricimab on a home optical coherence tomography-guided treatment schedule

Intravitreal injections of 6 mg faricimab on a Home OCT-guided treatment schedule

Locations(64)

Kent W. Small, MD, AMC

Glendale, California, United States

Loma Linda University

Loma Linda, California, United States

East Bay Retina Consultants, Inc.

Oakland, California, United States

Kaiser Permanente - Oakland

Oakland, California, United States

Southern California Desert Retina Consultants, Inc.

Palm Desert, California, United States

UC Davis Health Eye Center

Sacramento, California, United States

Macula Retina Vitreous Institute

Torrance, California, United States

Bay Area Retina Associates A Medical Group

Walnut Creek, California, United States

Retina Consultants

Manchester, Connecticut, United States

National Ophthalmic Research Institute

Fort Myers, Florida, United States

National Ophthalmic Research Institute

Fort Myers, Florida, United States

University of Florida- Jacksonville

Jacksonville, Florida, United States

Florida Retina Institute, James A. Staman, MD, PA- Jacksonville

Jacksonville, Florida, United States

Argus Research Center, Inc

Naples, Florida, United States

Southeast Eye Institute, P.A. dba Eye Associates of Pinellas

Pinellas Park, Florida, United States

Retina Associates of Sarasota

Sarasota, Florida, United States

Sarasota Retina Institute

Sarasota, Florida, United States

Retina Associates of Florida, LLC

Tampa, Florida, United States

Southeast Retina Center, P.C.

Augusta, Georgia, United States

Thomas Eye Group

Sandy Springs, Georgia, United States

Northwestern Memorial Group

Chicago, Illinois, United States

Rush University Medical Center

Chicago, Illinois, United States

UIC - Dept of Ophthalmology & Visual Sciences

Chicago, Illinois, United States

The Trustees of Indiana University

Indianapolis, Indiana, United States

Midwest Eye Institute

Indianapolis, Indiana, United States

Wolfe Clinic, P.C.- West Des Moines

West Des Moines, Iowa, United States

Mid-America Retina Consultants, P.A.

Overland Park, Kansas, United States

University of Kentucky Advanced Eye Care

Lexington, Kentucky, United States

Elman Retina Group, BA

Baltimore, Maryland, United States

Johns Hopkins University

Baltimore, Maryland, United States

Valley Eye Physicians and Surgeons

Ayer, Massachusetts, United States

Joslin Diabetes Center

Boston, Massachusetts, United States

Henry Ford Health System

Detroit, Michigan, United States

Retina Associates of Michigan

Grand Blanc, Michigan, United States

Associated Retinal Consultants, P.C.

Royal Oak, Michigan, United States

Associated Retinal Consultants

Traverse City, Michigan, United States

The Retina Institute

St Louis, Missouri, United States

Associated Retinal Surgeons d/b/a Mid Atlantic Retina

Cherry Hill, New Jersey, United States

New York University Langone Health

New York, New York, United States

Macula Care

New York, New York, United States

Vitreous Retina Macula Consultants of NY - VRMNY

New York, New York, United States

Retina Associates of Western NY, P.C.

Rochester, New York, United States

The Cleveland Clinic Foundation DBA Cleveland Clinic Lerner College of Medicine

Cleveland, Ohio, United States

Retina Vitreous Center

Edmond, Oklahoma, United States

Verum Research LLC

Eugene, Oregon, United States

Oregon Health & Science University

Portland, Oregon, United States

Cascade Medical Research Institute, LLC

Springfield, Oregon, United States

Retina Vitreous Consultants

Monroeville, Pennsylvania, United States

The Trustees of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Hilton Head Retina Institute

Hilton Head Island, South Carolina, United States

Ophthalmology Ltd.

Sioux Falls, South Dakota, United States

Southeastern Retina Associates, P.C.

Knoxville, Tennessee, United States

Austin Research Center for Retina

Austin, Texas, United States

Retina Consultants of Texas, PA

Bellaire, Texas, United States

UT Southwestern Medical Center

Dallas, Texas, United States

Southwest Retina Consultants

El Paso, Texas, United States

Baylor College of Medicine, Baylor Eye Physicians and Surgeons

Houston, Texas, United States

Texas Retina Associates

Lubbock, Texas, United States

Retina Associates of South Texas

San Antonio, Texas, United States

Retinal Consultants of Texas

San Antonio, Texas, United States

The Board of Regents of the University of Wisconsin System

Madison, Wisconsin, United States

Eye Clinic of Wisconsin

Wausau, Wisconsin, United States

Chow Berger Koushan Medicine Professional Corporation o/a Toronto Retina Institute

North YORK, Ontario, Canada

University Health Network

Toronto, Ontario, Canada

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NCT05904028

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