Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

This study is looking at how electroconvulsive therapy (ECT) — a treatment that uses brief electrical pulses to the brain to relieve severe depression — affects brain network activity and sleep patterns. Researchers hope to better understand why ECT works and how it changes brain function. **You may be eligible if...** - You have been referred for ECT to treat severe, treatment-resistant depression (unipolar major depression or bipolar depression) that has not responded to at least two antidepressant medications - This would be your first course of ECT **You may NOT be eligible if...** - You have been diagnosed with schizophrenia or schizoaffective disorder - You are unable to tolerate the sleep-monitoring headband device used in the study Talk to your doctor to see if this trial is right for you.