RecruitingPhase 2NCT05910177

Neoadjuvant Treatment of Neuroendocrine Cervix Carcinomar With Camrelizumab Combined With Etoposide and Cisplatin

A Single Arm, Exploratory Clinical Study on the Neoadjuvant Treatment of Neuroendocrine Cervix Carcinoma With Camrelizumab Combined With Etoposide and Cisplatin


Sponsor

Fujian Cancer Hospital

Enrollment

30 participants

Start Date

Dec 28, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a single arm, exploratory clinical study aimed at evaluating the efficacy and safety of karelizumab combined with etoposide and cisplatin in the neoadjuvant treatment of neuroendocrine cervix carcinoma.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of an immunotherapy drug (camrelizumab) with chemotherapy (etoposide + cisplatin) as a treatment given before surgery for a rare and aggressive type of cervical cancer called neuroendocrine cervical carcinoma, in women who are candidates for surgery. **You may be eligible if...** - You are a woman aged 18–75 with confirmed neuroendocrine cervical cancer (the neuroendocrine component is more than 60% of the tumor) - Your cancer is at stage I or II and can be surgically removed based on a specialist's assessment - You have at least one measurable tumor - Your blood counts, liver, and kidney function are within acceptable ranges - You are in good general health (ECOG 0–1) **You may NOT be eligible if...** - You have had previous chemotherapy, radiation, or immunotherapy for any cancer - Your cancer has spread to distant organs - You have an active autoimmune disease or history of significant autoimmune conditions - You have HIV/AIDS, organ transplant history, or severe immune deficiency - You are pregnant or breastfeeding - You have significant heart problems or a history of interstitial lung disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGKarelizumab combined with etoposide and cisplatin

Karelizumab:200 mg,ivgtt,D1,q3w; Cisplatin:75 mg/m2,ivgtt,D1,q3w; Etoposide:100 mg/m2,ivgtt,D1\~3,q3w


Locations(1)

Fujian Cancer Hospital

Fuzhou, Fujian, China

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NCT05910177


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