RecruitingNot ApplicableNCT05911230

Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases

Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases- AiD GLIO Pilot Trial

Sponsor

University Hospital, Basel, Switzerland

Enrollment

10 participants

Start Date

Nov 24, 2022

Study Type

INTERVENTIONAL

Conditions

Glioblastoma (GBM)

Summary

This pilot study investigates whether advanced diffusion-weighted MRI (ADW-MRI) can differentiate between true tumor progression (TP) and a pseudoprogression (PsP) in patients with glioblastoma (GBM) or brain metastases.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses advanced MRI brain scans to help doctors tell the difference between a brain tumor growing back versus 'pseudoprogression' — a harmless side effect where treated tissue looks like new tumor growth on standard scans. **You may be eligible if...** - You have been diagnosed with glioblastoma or brain metastases - Your standard MRI shows possible tumor progression after your first treatment - You are being considered for surgery to remove the suspicious area - You can give informed consent **You may NOT be eligible if...** - You have any condition that makes MRI unsafe (e.g., a pacemaker or certain metal implants) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTAdvanced diffusion-weighted MRI (ADW-MRI)

An advanced diffusion weighted MRI-sequence will be performed in addition to the routine MRI-diagnostics. This will require the patient to be scanned for additional 30 minutes in a separate MRI-scanner. This technique offers the opportunity of higher sensitivity towards subtle tissue changes associated with increased specificity relating to damage of different tissue components of the CNS. In the case of surgical resection, the histopathological findings will be correlated to the findings of the ADW-MRI.