Renal Cancer Monitoring Based on ctDNA Methylomics: A Prospective Cohort Study (MEMORY Study)

This study is following people with newly diagnosed kidney cancer (renal cell carcinoma) before and after surgery to see whether ctDNA methylomics — detecting cancer DNA fragments in blood that carry chemical 'tags' — can predict cancer recurrence earlier than standard imaging. **You may be eligible if...** - You have been newly diagnosed with renal cell carcinoma - You have not yet received any treatment - You are scheduled for surgical removal of the kidney (radical surgery) - You have good performance status (ECOG 0–1) **You may NOT be eligible if...** - You have had other cancers previously - You have already received cancer treatment before surgery - You have active autoimmune disease - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.