Effects of rTMS on Food Choice in Anorexia Nervosa
Deciphering the Neural Mechanisms of Restrictive Eating in Anorexia Nervosa Using Repetitive Transcranial Magnetic Stimulation
New York State Psychiatric Institute
72 participants
Apr 24, 2023
INTERVENTIONAL
Conditions
Summary
This study will examine the impact of high-frequency repetitive transcranial magnetic stimulation on food choice behavior and related neural activity.
Eligibility
Inclusion Criteria9
- DSM-5 Diagnosis of Anorexia Nervosa
- Age 18-30 years
- Female
- Right-handed
- Body Mass Index (BMI) ≥ 16.0
- Voluntarily admitted to inpatient eating disorders unit at NYSPI
- Competent to provide informed consent
- English-speaking
- Medically stable
Exclusion Criteria13
- High risk of suicide
- Current substance use disorder or other co- morbid psychiatric condition requiring specialized treatment (e.g., psychosis)
- Diagnosis of major medical or neurological problem or taking medication that significantly increases risk for seizure or affects interpretation of findings (e.g., unstable hypertension, seizure disorder)
- Food restrictions (e.g., allergies) which impact greater than 30% of food choice task's choice options
- Indwelling ferromagnetic metallic object (e.g., pacemaker, pump), non- removable metal jewelry, medicinal patch or recent metallic ink tattoo
- History of seizure
- Diagnosis of epilepsy, stroke, multiple sclerosis, traumatic brain injury, Alzheimer's and other neurodegenerative diseases, meningoencephalitis or intracerebral abscess, or parenchymal or leptomeningeal cancers
- Prior exposure to TMS
- Pregnancy
- Currently breast-feeding
- Significant claustrophobia
- Implanted devices or stimulators
- Hearing loss (e.g., currently undergoing treatment with ototoxic medications or those with cochlear implants)
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Interventions
HF-rTMS is applied with a figure-of-8 coil using the Magstim TMS System. Participants receive one administration of HF-rTMS, delivered to the region of the right dorsolateral prefrontal cortex (DLPFC) with greatest resting-state functional connectivity to the dorsal striatum (individualized per participant). HF-rTMS is delivered at a frequency of 10 Hz for approximately 37 minutes (3000 total pulses).
Sham rTMS is applied with a figure-of-8 sham coil using the Magstim TMS System, which is identical to the active coil, replicates the sounds of HF-rTMS, and is designed to mimic sensations of HF-rTMS. Participants receive one administration of sham rTMS, delivered to the region of the right dorsolateral prefrontal cortex (DLPFC) with greatest resting-state functional connectivity to the dorsal striatum (individualized per participant). Sham rTMS is delivered for approximately 37 minutes (3000 total pulses).
Locations(1)
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NCT05918835