Aspirin for Postpartum Patients With Preeclampsia
Acetylsalicylic Acid for Postpartum Preeclampsia: A Pilot Randomized Trial
MemorialCare Health System
86 participants
Jul 26, 2023
INTERVENTIONAL
Conditions
Summary
The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth. We hypothesize that taking aspirin for the first week after giving birth will enhance recovery from preeclampsia by decreasing the levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to be a main contributor to the development of preeclampsia, and speeding up return to a normal blood pressure.
Eligibility
Inclusion Criteria2
- Preeclampsia with severe features diagnosed during delivery admission, as defined by ACOG criteria.
- Pre- and postnatal care provided by the Long Beach Memorial Ob/Gyn resident or Maternal-Fetal Medicine clinic.
Exclusion Criteria7
- Patient age \<18 years old
- Non-English or Non-Spanish speaking
- Chronic hypertension diagnosed before 20 weeks' gestation
- Known allergy, prior adverse reaction, or any medical condition in which aspirin is contraindicated (nasal polyps, gastric or duodenal ulcers, history of gastrointestinal bleeding, severe hepatic dysfunction)
- Aspirin prescribed postpartum for any other medical condition
- Bleeding disorder
- Breastfeeding an infant with thrombocytopenia
Interventions
Aspirin 81 mg 1 tablet by mouth. Participants randomized to receive aspirin in addition to standard blood pressure management will receive the study medication nightly at 20:00, with first dose initiated within 24 hours of delivery.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05924971