RecruitingPhase 2NCT05924971

Aspirin for Postpartum Patients With Preeclampsia

Acetylsalicylic Acid for Postpartum Preeclampsia: A Pilot Randomized Trial


Sponsor

MemorialCare Health System

Enrollment

86 participants

Start Date

Jul 26, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth. We hypothesize that taking aspirin for the first week after giving birth will enhance recovery from preeclampsia by decreasing the levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to be a main contributor to the development of preeclampsia, and speeding up return to a normal blood pressure.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether low-dose aspirin, taken after delivery, can reduce the risk of complications in women who had preeclampsia — a serious pregnancy condition involving high blood pressure and organ stress — during their delivery hospitalization. Preeclampsia can increase the risk of ongoing cardiovascular problems after birth, and aspirin's blood-thinning properties may help reduce that risk. **You may be eligible if:** - You had preeclampsia with severe features during your delivery admission (as defined by standard obstetric guidelines) - Your prenatal and postnatal care was provided by Long Beach Memorial's OB/GYN or Maternal-Fetal Medicine team **You may NOT be eligible if:** - You are under 18 years old - You speak neither English nor Spanish - You had high blood pressure diagnosed before 20 weeks of pregnancy (chronic hypertension) - You have a known allergy or previous bad reaction to aspirin, or a medical condition where aspirin is unsafe (such as nasal polyps, stomach ulcers, history of GI bleeding, or severe liver disease) - You are currently taking aspirin for another medical reason after delivery - You have a bleeding disorder - You are breastfeeding a baby with low platelet counts Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAspirin 81Mg Ec Tab

Aspirin 81 mg 1 tablet by mouth. Participants randomized to receive aspirin in addition to standard blood pressure management will receive the study medication nightly at 20:00, with first dose initiated within 24 hours of delivery.


Locations(1)

Miller Children's and Women's Hospital, Long Beach/MemorialCare Long Beach

Long Beach, California, United States

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NCT05924971


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