Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III Colorectal Cancer Survivors

This study examines whether an 8-week supervised exercise program changes the gut bacteria (microbiome) in people who have completed treatment for stage II–III colorectal cancer, and whether these changes are linked to health outcomes. **You may be eligible if...** - You are between 18 and 70 years old - You have a history of stage II–III colorectal cancer with no evidence of current cancer - It has been 60 days to 3 years since your last cancer treatment - Your BMI is between 18.5 and 30 - You exercise less than 60 minutes of moderate-to-vigorous activity per week - You are a non-smoker (no smoking in the past 30 days) - You are able to attend exercise sessions at the study center **You may NOT be eligible if...** - You have taken antibiotics, antifungals, or antiparasitics in the past 6 months - You have a colostomy or ileostomy - You have inflammatory bowel disease (Crohn's or ulcerative colitis) - You are currently obese (BMI 30 or higher) or underweight (BMI below 18.5) - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.