RecruitingNCT05931419

High-Risk prostatE Cancer radiatiOn Versus surgERy

High-Risk prostatE Cancer radiatiOn Versus surgERy (RECOVER)

Sponsor

Comprehensive Cancer Centre The Netherlands

Enrollment

837 participants

Start Date

Feb 16, 2023

Study Type

OBSERVATIONAL

Conditions

Prostate Cancer Prostate Adenocarcinoma

Summary

Prospective cohort study comparing robot-assisted radical prostatectomy and external beam radiotherapy +/- androgen deprivation therapy for high-risk non-metastatic prostate cancer in terms of health-related quality of life, functional outcomes, cost-effectiveness, progression-free survival and distant metastasis-free survival.

Eligibility

Sex: MALEMin Age: 50 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This Dutch study compares two treatments for high-risk prostate cancer — surgery (robotic-assisted radical prostatectomy) versus radiation therapy combined with hormone therapy — to determine which gives better long-term cancer control and quality of life. **You may be eligible if...** - You have been newly diagnosed with high-risk prostate cancer that has not spread (non-metastatic) - Your cancer is stage T3a or T3b, OR your Gleason/ISUP grade is 4 or 5, OR your PSA at diagnosis was above 20 ng/mL - You are fit for either surgery or radiation therapy - You live in the Netherlands and can read and understand Dutch **You may NOT be eligible if...** - Your prostate cancer is not an adenocarcinoma - You were diagnosed or treated outside the Netherlands - You are planned to receive androgen receptor targeted agents (a specific hormone therapy) as part of initial treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(28)

Noordwest Ziekenhuisgroep

Alkmaar, Netherlands

Amsterdam UMC

Amsterdam, Netherlands

Antoni van Leeuwenhoek Ziekenhuis

Amsterdam, Netherlands

BovenIJ ziekenhuis

Amsterdam, Netherlands

OLVG

Amsterdam, Netherlands

Wilhelmina Ziekenhuis

Assen, Netherlands

Rode Kruis Ziekenhuis

Beverwijk, Netherlands

Albert Schweitzer Ziekenhuis

Dordrecht, Netherlands

Catharina Ziekenhuis

Eindhoven, Netherlands

Admiraal de Ruyter Ziekenhuis

Goes, Netherlands

Martini ziekenhuis

Groningen, Netherlands

Universitair Medisch Centrum Groningen

Groningen, Netherlands

Saxenburgh Medisch Centrum

Hardenberg, Netherlands

St Jansdal

Harderwijk, Netherlands

Spaarne Gasthuis

Hoofddorp, Netherlands

Treant

Hoogeveen, Netherlands

Dijklander Ziekenhuis

Hoorn, Netherlands

Leids Universitair Medisch Centrum

Leiden, Netherlands

Canisius Wilhelmina Ziekenhuis

Nijmegen, Netherlands

Radboudumc

Nijmegen, Netherlands

Erasmus Medisch Centrum Rotterdam

Rotterdam, Netherlands

Franciscus Gasthuis & Vlietland

Rotterdam, Netherlands

Maasstad Ziekenhuis

Rotterdam, Netherlands

Ommelander Ziekenhuis

Scheemda, Netherlands

Haaglanden Medisch Centrum

The Hague, Netherlands

Verbeeten Instituut

Tilburg, Netherlands

Maxima Medisch Centrum

Veldhoven, Netherlands

Zaans Medisch Centrum

Zaandam, Netherlands

View Full Details on ClinicalTrials.gov

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NCT05931419

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