RecruitingNCT05934474

Biocollection on Peripheral Inflammation

Biocollection on Peripheral Inflammation in Psychiatric Pathologies


Sponsor

Nantes University Hospital

Enrollment

300 participants

Start Date

Mar 19, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Most psychiatric research is based on the nosographic classifications used in current practice. At present, there is no diagnostic or prognostic biomarker for psychiatric pathologies commonly used in clinical practice. The study hypothesis is that peripheral inflammatory biomarkers could be common to several psychiatric disorders, in particular psychotic disorders (bipolar disorder, schizophreniform disorder, schizophrenia, depressive episode with psychotic features). The aim of this project is to set up a bio-collection of biological samples (peripheral blood samples) with associated phenotypic data (assessment of various symptoms using standardized scales in patients whose blood is sampled). The setting up of this cohort follows on from work carried out on a PsyCourse cohort also using a transdiagnostic approach in psychiatry, in order to be able to collaborate within a European research project.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting blood samples from people with serious psychiatric conditions to study inflammation — specifically, how the immune system is activated in conditions like schizophrenia, bipolar disorder, and depression with psychotic features. This is a biobank study, not a treatment trial. **You may be eligible if...** - You are 18 or older and weigh at least 45 kg - You have been diagnosed by a psychiatrist with one of the following: major depressive episode with psychotic features, bipolar disorder type I or II, schizoaffective disorder, schizophrenia, or schizophreniform disorder - You are currently receiving psychiatric care at Nantes University Hospital (France) - You are covered by social security and have given informed consent **You may NOT be eligible if...** - You are pregnant - You have had cancer in the last 5 years - You received a vaccination in the last 4 weeks - You have an active or chronic infection - You have had an organ transplant or autoimmune disease - You have hearing impairment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALPeripheral venipuncture blood sampling, as part of standard care procedures

Collection of 36 mL of blood

OTHERInterview with a psychiatrist

Research project data collection


Locations(1)

Nantes University Hospital

Nantes, France

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NCT05934474


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