RecruitingNot ApplicableNCT05940233
Comparison of Rate of Complete Abortion Between Letrozole Plus Misoprostol vs Misoprostol Alone
Comparison of Rate of Complete Abortion Between Letrozole Plus Misoprostol vs Misoprostol Alone in First Trimester Pregnancy
Sponsor
Queen Savang Vadhana Memorial Hospital, Thailand
Enrollment
70 participants
Start Date
Jun 30, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
Comparison of rate of complete abortion between Letrozole plus Misoprostol versus Misoprostol alone in first trimester pregnancy
Eligibility
Sex: FEMALE
Inclusion Criteria6
- Diafnoed Early pregnancy loss by TVS according to ACOG Practice bulletin 2018
- GA <= 14 weeks
- Os open <= 1 cm and no conceptus per os
- Hematicrit >= 30
- Systolic blood pressure >= 95 mmHg
- Informed consent done and can follow up and comunicate in Thai language
Exclusion Criteria9
- Allerguc to Letrozole or Misoprostol
- Intrauterine contraceptive device use
- Breast feeding
- Diagnoed with ectopic pregnancy or undiagnoed adnexal mass
- Severe or recurrent liver disease or AST or ALT more than or equal to 3 times of upper normal limit
- Multiple pregnancy
- Myoma uteri that involves the endometrium ex. Submucous myoma uteri
- Thromboembolism or has a history of thromboembolism
- Serum creatinine >= 2
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Interventions
DRUGLetrozole
In the experimental group, we give the Letrozole 10 mg PO daily on the 4th day before Misoprostol 800 mcg SL on the 4th day. In the control group, we give Misoprostol 800 mcg SL on the 4th day.
Locations(1)
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NCT05940233