RecruitingNCT05942729

Etiological DiagnOsis of caRdiac Diseases Based on echoCardiograpHIc Images and Clinical Data.


Sponsor

Hospices Civils de Lyon

Enrollment

1,000 participants

Start Date

Jan 1, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Research hypothesis - Recent studies have shown that high-dimensional descriptors of the cardiac function can be efficiently exploited to characterize targeted pathologies. In this project, the investigators hypothesize that echocardiograms possess a wealth of information that is currently under-exploited and that, combined with relevant patient data, will allow the development of robust and accurate digital tools for etiological diagnosis. Objectives - Based on key advances recently obtained in image analysis, notably by members of the consortium, the objective of this project is to develop rigorous and explainable cardiac disease prediction models from echocardiography based on the transformer paradigm (AI). The strength of this study lies in the development of a strong AI framework to model the complex interactions between high-quality image-based measurements extracted from echocardiograms and relevant patient data to automatically predict etiological diagnosis of cardiac diseases


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using an AI system to analyze heart ultrasound images (echocardiograms) and clinical data to help identify the underlying cause of heart diseases. The goal is to improve how accurately doctors can diagnose different types of heart conditions. **You may be eligible if...** - You have had a heart ultrasound (echocardiogram) with good image quality **You may NOT be eligible if...** - You are under 18 years old - You are under legal guardianship or a protective legal arrangement that limits your ability to consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERDetermine the etiology of hypokinetic and hypertrophic heart disease on transthoracic echocardiography data alone

The origin of the pathology will have been previously diagnosed for each patient thanks to complementary examinations performed as part of routine care (e.g. cardiac CT, cardiac MRI, coronary angiography, thorough biology, nuclear medicine). This information will be used (i) to guide the learning of the AI method developed during the project from a sub-population (80% of the collected database will be used to train the algorithms); (ii) to serve as an evaluation criterion from a test sub-population (remaining 20% of the collected database)


Locations(1)

Hopital Lyon Sud

Pierre-Bénite, France

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NCT05942729


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