Development and Application of Comprehensive Intervention Techniques for Adolescent Depression

This study is developing and testing a comprehensive intervention combining therapy, brain stimulation, and physical training for teenagers with depression. Researchers want to see if this multi-pronged approach can reduce depression symptoms more effectively than standard treatment. **You may be eligible if...** - You meet the diagnostic criteria for depression (DSM-5) without psychotic features - You scored at or above the required cutoffs on depression rating scales - You are having a first or recurring episode of depression and have not received antidepressants or formal psychotherapy in the past 2 months - You are right-handed and of Han Chinese ethnicity **You may NOT be eligible if...** - You have another mental health diagnosis (such as ADHD, autism, or intellectual disability) - You have an active infection, autoimmune disease, trauma, or are receiving hormone therapy - You have a history of brain injury or conditions affecting brain function - You are currently pregnant Talk to your doctor to see if this trial is right for you.