RecruitingNCT05945602

Neurophysiologic Biomarkers for Cognitive Rehabilitation

Optimization of Neurophysiologic Biomarkers for Rehabilitation Interventions in Veterans With Chronic Psychosis


Sponsor

VA Office of Research and Development

Enrollment

80 participants

Start Date

Oct 1, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Cognitive symptoms of schizophrenia interfere with daily life-from managing self-care, to more complex tasks like taking medications and living independently. Unfortunately, these cognitive symptoms are not corrected by 'standard of care' treatments (antipsychotic medications), although some schizophrenia patients may experience modest clinical and cognitive benefits from cognitive remediation. To enhance the clinical impact of cognitive remediation and other rehabilitative interventions for Veterans living with chronic psychosis, this study will develop novel brain-based tools to help identify those Veterans who are most likely to benefit from pro-cognitive therapies. These studies may advance predictive algorithms that improve functional outcomes and life quality in Veterans with schizophrenia.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is looking for brain activity patterns (called biomarkers) that can predict how well someone with schizophrenia or a similar psychotic disorder will respond to cognitive rehabilitation — a type of therapy that helps improve thinking and memory skills. The study also includes healthy volunteers for comparison. **You may be eligible if...** - You have a diagnosis of a chronic psychotic disorder (e.g., schizophrenia, schizoaffective disorder), OR you are a healthy individual with no active mental health condition - You speak and read English fluently - You have no significant hearing or vision impairment **You may NOT be eligible if...** - You have used substances (other than cannabis) in the past 30 days - You have a significant neurological illness or intellectual disability - You are a healthy volunteer with a past diagnosis of a psychotic disorder - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERNeurophysiologic Biomarker Assessments

Non-invasive electroencephalography will be recorded to derive neurophysiologic biomarkers.


Locations(1)

VA San Diego Healthcare System, San Diego, CA

San Diego, California, United States

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NCT05945602


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