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RecruitingEarly Phase 1NCT05946798

Role of NADPH Oxidase in Microvascular Dysfunction Following GDM

Sponsor

Anna Stanhewicz, PhD

Enrollment

40 participants

Start Date

Aug 30, 2023

Study Type

INTERVENTIONAL

Conditions

Gestational DiabetesOxidative StressVascular Endothelial Function

Summary

The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Acetylcholine and a drug called Insulin aspart for people with gestational diabetes, oxidative stress, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include women aged 18 Years to 50 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAcetylcholine

acetylcholine is perfused at 10 ascending concentrations (10\^-10M - 10\^-1 M) for 5 minutes each

DRUGInsulin aspart

insulin aspart is perfused at 5 ascending concentrations (10\^-8M - 10\^-4 M) for 10 minutes each

Locations(1)

University of Iowa

Iowa City, Iowa, United States

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NCT05946798

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