CT Quantitative Assessment of Interstitial Lung Disease
CT Quantitative Assessment of Interstitial Lung Disease Using Visual Score and Lung Densitometry Methods and Its Correlation With Pulmonary Function Tests
Assiut University
70 participants
Dec 1, 2023
OBSERVATIONAL
Conditions
Summary
Interstitial lung disease (ILD) refers to a broad category of heterogeneous lung diseases with different etiologies and features characterized by inflammation and fibrosis of the lung parenchyma and manifested as exertional dyspnea, interstitial patterns on high resolution computed tomography (HRCT), and abnormal pulmonary function tests (PFTs) The aim of this study is to investigate is there any correlation between changes seen in the lung parenchyma by HRCT and the pulmonary functions of the patients.
Eligibility
Inclusion Criteria2
- Diagnosis of ILD (based on clinical, radiological, and pulmonary function criteria +/- histopathological criteria).
- Availability of CT chest DICOM images and pulmonary function test results (within a 2-weeks period from each other).
Exclusion Criteria5
- Pregnancy
- Pulmonary edema.
- Primary pulmonary hypertension;
- Chronic obstructive pulmonary disease
- Congestive heart failure
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
CT chest in our institution will be done with standard high resolution protocol . No I.V contrast will be given. Scans will be obtained during full inspiration in supine position from the thoracic inlet to the level of the diaphragm. Patients with CT chest performed outside our institution will be reviewed in DICOM format and assessed for its compatibility to be integrated into the computer-based analysis software.
Spirometry will be performed using standard techniques according to ATS-ERS criteria 2019 . Spirometry device (Zan 300, NSPIRE HEALTH GMBH Co.) will be used. Percentage predicted values (%pred) will be calculated based on reference values for healthy adults. All patients will be required to undergo spirometry in a reproducible way, and the best values will be reported. Spirometry should meet international acceptability and repeatability standards
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05947422