RecruitingPhase 2NCT05948566

Strategy for Improving Stroke Treatment Response

Strategy for Improving Stroke Treatment Response (SISTER) Trial

Sponsor

Translational Sciences, Inc.

Enrollment

300 participants

Start Date

Mar 18, 2024

Study Type

INTERVENTIONAL

Conditions

Ischemic Stroke

Summary

SISTER is a Phase-II, prospective, randomized, placebo-controlled, blinded, dose finding trial that aims to determine the safety and preliminary efficacy of TS23, a monoclonal antibody against the alpha-2 antiplasmin (a2-AP), in acute ischemic stroke.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called TS23 for people with ischemic stroke. The study is currently recruiting participants at 52 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALTS23

Monoclonal antibody

Locations(52)

University of Alabama Hospital

Birmingham, Alabama, United States

Banner University Medical Center

Phoenix, Arizona, United States

Mayo Clinic Phoenix

Phoenix, Arizona, United States

Banner University Medical Center - Tucson

Tucson, Arizona, United States

UCSD Health La Jolla

La Jolla, California, United States

Kaiser Permanente Los Angeles

Los Angeles, California, United States

Sutter Medical Center

Sacramento, California, United States

UCSD Medical Center- Hillcrest Hospital

San Diego, California, United States

Hartford Hospital

Hartford, Connecticut, United States

Yale New Haven Hospital

New Haven, Connecticut, United States

Christiana Hospital

Newark, Delaware, United States

UF Health Shands Hospital

Gainesville, Florida, United States

Jackson Memorial Hospital

Miami, Florida, United States

Grady Memorial Hospital

Atlanta, Georgia, United States

University of Chicago Medical Center

Chicago, Illinois, United States

University of Iowa Hospitals & Clinics

Iowa City, Iowa, United States

Baptist Healthcare System, Inc.

Lexington, Kentucky, United States

University of Louisville Hospital

Louisville, Kentucky, United States

Brigham and Women's Hospital

Boston, Massachusetts, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

M Health Fairview Ridges Hospital

Burnsville, Minnesota, United States

M Health Fairview Southdale Hospital

Edina, Minnesota, United States

M Health Fairview University of Minnesota Medical Center

Minneapolis, Minnesota, United States

United Hospital

Saint Paul, Minnesota, United States

Barnes Jewish Hospital

St Louis, Missouri, United States

JFK Medical Center

Edison, New Jersey, United States

NYU Langone Health

Brooklyn, New York, United States

Buffalo General Medical Center

Buffalo, New York, United States

North Shore University Hospital

Manhasset, New York, United States

Mount Sinai West

New York, New York, United States

The Mount Sinai Hospital

New York, New York, United States

NYP Columbia University Medical Center

New York, New York, United States

SUNY Upstate Medical University

Syracuse, New York, United States

Westchester Medical Center

Valhalla, New York, United States

Duke University Hospital

Durham, North Carolina, United States

Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, United States

University of Cincinnati Medical Center

Cincinnati, Ohio, United States

OSU Wexner Medical Center

Columbus, Ohio, United States

Ascension St. John

Tulsa, Oklahoma, United States

Providence St. Vincent Medical Center

Portland, Oregon, United States

Saint Luke's Hospital of Bethlehem Pennsylvania

Bethlehem, Pennsylvania, United States

Temple University Hospital

Philadelphia, Pennsylvania, United States

Rhode Island Hospital

Providence, Rhode Island, United States

Medical University of South Carolina University Hospital

Charleston, South Carolina, United States

Prisma Health Greenville Memorial

Greenville, South Carolina, United States

Methodist University Hospital

Memphis, Tennessee, United States

Memorial Hermann Texas Medical Center

Houston, Texas, United States

University of Utah Healthcare

Salt Lake City, Utah, United States

UVA Medical Center

Charlottesville, Virginia, United States

VCU Medical Center

Richmond, Virginia, United States

Harborview Medical Center

Seattle, Washington, United States

Ascension Columbia St. Mary's Hospital

Milwaukee, Wisconsin, United States

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NCT05948566

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Strategy for Improving Stroke Treatment Response

Conditions

Summary

Eligibility

Plain Language Summary

Interventions

Locations(52)

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