Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr

This study is evaluating whether a specialized type of PET scan called PSMA-PET CT can improve how doctors monitor low-risk prostate cancer during active surveillance — a watchful waiting approach where the cancer is tracked but not immediately treated. The hope is that this scan can detect any significant changes earlier than standard testing. **You may be eligible if...** - You are a male aged 18 or older - You have been diagnosed with low or favorable intermediate-risk prostate cancer (confirmed by biopsy) - Your PSA level is below 20 ng/mL - You are willing to undergo yearly PSMA-PET CT scans, MRI, and prostate biopsies - You are committed to active surveillance rather than immediate treatment **You may NOT be eligible if...** - You have had prior treatment for prostate cancer - You have had systemic therapy (e.g., hormone therapy) for prostate cancer - You are unable to undergo the required imaging or biopsies - Your life expectancy is less than 10 years - Your cancer was diagnosed more than 15 months ago Talk to your doctor to see if this trial is right for you.