Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury

This study is testing whether stem cells taken from a patient's own fat tissue and injected back into their body can help treat the long-term effects of a traumatic brain injury (TBI). Researchers hope this approach may promote healing and improve neurological function in people with lasting disability from a head injury. **You may be eligible if...** - You are between 18 and 55 years old with confirmed chronic traumatic brain injury from a closed head trauma - Your injury happened at least 6 months ago and no more than 20 years ago - You have lasting neurological disability (GOS-E score between 3 and 6) - You can communicate in English or Spanish - Your injury is unlikely to improve with current standard treatments **You may NOT be eligible if...** - You have a history of cancer, HIV, hepatitis B or C, or syphilis - You have a serious intellectual disability or uncontrolled psychiatric condition - You have a history of spinal cord injury - You have liver or kidney disease at concerning levels - You have had prior stem cell, gene, or cellular therapy - You have metal implants that would prevent MRI scanning - You are pregnant or unwilling to use contraception Talk to your doctor to see if this trial is right for you.