Breast Cancer Exercise Intervention Study
Breast Cancer Exercise Intervention Study (BREXINT)
National Cancer Centre, Singapore
2,156 participants
Jul 1, 2023
INTERVENTIONAL
Summary
This is a 24-week exercise programme consisting of aerobic exercise and muscle strength training, 3 sessions per week. The first 9 sessions are supervised by physiotherapists in person, followed by 63 sessions monitored remotely (video) or supervised by trainers at ActiveSG (Sport Singapore) gyms.
Eligibility
Inclusion Criteria5
- Patients with histologically or cytologically proven stage 1, 2, or 3 breast cancer
- Patients who have undergone curative breast surgery
- Patients who have received (neo)adjuvant chemotherapy (if given) and/or radiotherapy (if given)
- Females aged 21 years and older
- ≤ 8 weeks from breast surgery, or the last adjuvant chemotherapy or radiotherapy session, whichever is latest.
Exclusion Criteria2
- Cardiovascular, respiratory, musculoskeletal problems that preclude moderate physical activity.
- Major medical problems that are deemed by the investigator to be unsuitable for enrollment.
Interventions
Aerobic exercise consists of 20-minute brisk walks or jogs (5-6 km/h) on the treadmill each session, reaching a heart rate corresponding to 50%-70% of the patient's VO2max (VO2max is determined before embarking on the exercise programme). Study participants are expected to aim for 50% VO2max at the start of the exercise programme, and gradually increasing to 70% VO2max in subsequent exercise sessions. Strength training comprises a series of circuit resistance exercises targeting the major muscle groups. Patients will perform 2-4 sets of these exercises each session, 8-10 repetitions per set. Both aerobic exercise and strength training are done in the same session. With warm-up and cool-down, each session is estimated to take up 1 hour.
Usual care group.
Locations(3)
View Full Details on ClinicalTrials.gov
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NCT05957068