Effects of Remote Ischemic Preconditioning on Peripheral Blood Biomarkers in Healthy Adults (EMINENT)
Effects of Remote Ischemic Preconditioning on Peripheral Blood Biomarkers in Healthy Adults (EMINENT): a Single-centre, Open-label, Randomized Controlled Clinical Trial
First Affiliated Hospital Xi'an Jiaotong University
60 participants
Jun 27, 2024
INTERVENTIONAL
Conditions
Summary
The aim of this study is to investigate the effects of remote ischaemic preconditioning on the peripheral blood characteristics of healthy adults and to explore the possible mechanisms for improving ischaemia/reperfusion injury and its protective effects on the cardiovascular system.
Eligibility
Inclusion Criteria3
- Aged 18 to 45 years;
- Be in good health;
- Consent to participate in the clinical trial and sign the informed consent form.
Exclusion Criteria13
- Abnormal results in biochemical checks and physiological indicators.
- Cardiovascular and cerebrovascular diseases: hypertension, coronary heart disease, congenital heart disease, cerebrovascular alterations, etc.
- Endocrine diseases: diabetes, thyroid disorders, etc.
- Hematologic diseases: anemia, paroxysmal hemoglobinuria, primary thrombocytosis, etc.
- Infectious diseases: hepatitis B, hepatitis C, syphilis, etc.
- Cancer.
- Neurological and psychiatric disorders.
- Vascular diseases: peripheral vascular disease, Raynaud's syndrome, thromboembolic diseases.
- Major trauma or surgery within the last six months.
- Pregnant or breastfeeding women.
- Upper limbs unsuitable for compression treatment: history of upper limb surgery, presence of tissue damage and limb deformity, and concomitant hemorrhagic diseases.
- Recent circumstances that may affect results: blood donors within the last month, any medication taken within the last month, fever within the last week, women within their menstrual cycle or within 7 days before the start of menstruation.
- Patients who refuse to sign the informed consent form for participation in this study.
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Interventions
The participants rested in the supine position for 5 minutes, then turn on the ischaemic preconditioning apparatus and place the automatically programmed blood pressure cuff on both upper arms of the participant, pressurize to 200 mmHg, pressurize for 5 minutes, rest for 5 minutes, perform 4 cycles for a total of 40 minutes each time. The training for participants in group A will be performed once daily, while for participants in group B the training will be performed twice daily. And heart rate and blood pressure before and after each training will be recorded for 7 days.
Locations(1)
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NCT05957523