BivaLirudin versUS Heparin in Extracorporeal Membrane Oxygenation
BivaLirudin versUS Heparin in ECMO - A Registry-embedded, Randomised, Open Label, Feasibility Trial Comparing Two Anticoagulation Strategies in Patients on Extracorporeal Membrane Oxygenation (ECMO)
Sydney Local Health District
80 participants
May 1, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this open label randomised clinical trial is to compare Bivalirudin versus Heparin for anticoagulation in patients requiring extracorporeal membrane oxygenation support. The main question it aims to answer are include the ability to maintain anticoagulation within defined therapeutic range, bleeding and thrombotic complications and a comparison of the total cost of anticoagulation care. Participants will be randomised to either anticoagulation with Bivalirudin or anticoagulation with Unfractionated Heparin.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Unfractionated Heparin protocol with target anti-Xa of 0.3-0.5 IU/mL
Bivalirudin protocol with target aPTT 50-70 seconds
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05959252