Impact of Endometrial Compaction on Reproductive Outcomes After Cryotransfer of Euploid Embryos in a Natural Cycle
Impact of Endometrial Compaction on Reproductive Outcomes After Cryotransfer of Euploid Embryos in a Natural Cycle: Prospective Cohort Study
Instituto Bernabeu
206 participants
Jun 15, 2022
OBSERVATIONAL
Conditions
Summary
Multicenter prospective observational cohort study, comparing ongoing pregnancy rates in natural cycles for euploid embryo transfer in patients who present endometrial compaction at the time of the transfer versus those who have a stable or greater endometrial thickness with respect to the estrogenic phase.
Eligibility
Inclusion Criteria5
- Aged 18 to 50 years
- Primary or secondary infertility
- Normal uterine cavity
- Endometrial preparation in a modified natural cycle for single embryo transfer
- Embryo in blastocyst state from own oocyte or oocyte donation cycles, who had normal results on preimplantation genetic testing for aneuploidy (PGT-A) via trophectoderm biopsy.
Exclusion Criteria4
- Uterine or endometrial disease (multiple myomatosis \[>3 fibroids of > 3 cm\], adenomyosis, Asherman syndrome)
- Difficulties in correctly measuring endometrial thickness due to a retroverted or tilted uterus
- History of recurrent implantation failure (3 or more transferred blastocysts of good quality, from their own oocyte \[<35 years\] or oocyte donation); recurrent early Pregnancy Loss (the loss of two or more pregnancies before 10 weeks of gestational age.
- Suboptimal endometrial response (endometrium < 6 mm on the day of ovulation triggering).
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
An additional control scan will be performed vaginally the day of the embryo transfer. Rest of follow up and treatment will be executed as usually.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05960370