RecruitingNot ApplicableNCT05960890

Cohort Study of Chronic Heart Failure

Sponsor

Jiangsu Taizhou People's Hospital

Enrollment

1,000 participants

Start Date

Jun 8, 2023

Study Type

INTERVENTIONAL

Conditions

Heart Failure

Summary

The goal of this observational study is to learn about the influencing factors of chronic heart failure prognosis in heart failure patients. The main question it aims to answer is that what are the influencing factors of clinical outcomes in chronic heart failure. Participants will be collected multiple omics data such as phenotype group, environmental exposure group, intestinal microbiome, genome, metabolome, and noninvasive biomarkers.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Age ≥18 years;
Fulfill at least one of the following criteria：①History of chronic heart failure;②New-onset heart failure with LVEF \<50%；③New-onset heart failure with LVEF≧50%，E/e'≧15 and BNP\>400 pg/mL/NT-proBNP(\<50 years, \>450 pg/mL; 50\~75 years, \>900 pg/mL; \>75 years, \>1800 pg/mL)
Etiology: dilated cardiomyopathy, hypertensive heart disease, ischaemic cardiomyopathy, Non-severe valvular heart disease；
Primary post-discharge therapy: oral medication;
Sign the informed consent form.

Exclusion Criteria6

Patients with renal failure (Ccr\<30ml/min) or patients on dialysis therapy;
Various correctable secondary causes of cardiac insufficiency including hyperthyroid heart disease, anaemic heart disease, uncorrected congenital heart disease; severe valvular heart disease (including severe stenosis or closure of organic aortic and mitral valves);
Patients with indications for pacemaker implantation but have not received a pacemaker implant;
Patients with chronic obstructive pulmonary disease accompanied by type II respiratory failure.
Patients who cannot understand and sign an informed consent form.
Patients with mental illness, pregnant women, and other special populations.

Interventions

BEHAVIORALRemote monitoring assisted by community physicians

Patients upload data such as wristband data, blood pressure, weight through their mobile phones, while physicians can check the data on the platform. Upon detecting alerts, community physicians review participant-related medical information, conduct structured symptom assessments via "StarNet Home" platform/phone within 2 hours, and initiate protocol-guided interventions (e.g., diuretic adjustment for fluid overload).