Observational SIR-Spheres Study for the Treatment of Unresectable Liver Tumors (SIRtain Registry)

This study (the SIRtain Registry) is a real-world registry tracking patients who receive SIR-Spheres — tiny radioactive beads injected directly into the liver's blood supply to deliver targeted radiation to liver tumors — for either primary liver cancer (hepatocellular carcinoma) or colorectal cancer that has spread to the liver. **You may be eligible if...** - You are 18 or older - You have confirmed, unresectable (cannot be surgically removed) liver cancer (HCC) OR liver metastases from colorectal cancer that are no longer responding to chemotherapy - Your doctor has determined SIR-Spheres treatment is appropriate for you - You have not previously received SIR-Spheres treatment - You have signed informed consent **You may NOT be eligible if...** - You have had prior radiation treatment to the liver - You have already received SIR-Spheres previously - Your cancer is eligible for surgical removal - You do not meet other standard safety criteria for this type of radiation treatment Talk to your doctor to see if this trial is right for you.