Acetoacetate and Acetate Metabolism in Patients With Chronic Kidney Failure.(RENO-TEP)

This study (RENO-TEP) is investigating how the kidneys process certain energy-producing molecules called acetoacetate and acetate in people with chronic kidney disease. Researchers want to better understand the way the kidneys use these substances as fuel, which could help improve treatments for kidney failure in the future. Participants will undergo metabolic testing rather than receive an experimental treatment. **You may be eligible if...** - You have moderate chronic kidney disease (a kidney filtration rate between 30 and 60 mL/min) - Your BMI is between 18.5 and 40 - Your medications have been stable for at least 4 weeks **You may NOT be eligible if...** - You received cytotoxic (cancer-killing) therapy for kidney disease in the past 6 months - You have had an organ transplant - You have severe heart failure (Class IV) - You had a heart attack, stroke, or serious heart procedure in the past 12 weeks - You have active cancer requiring treatment - You have significant liver problems - You are pregnant or breastfeeding - You follow a ketogenic (very low-carb) diet or fast regularly - You drink more than 2 alcoholic drinks per day Talk to your doctor to see if this trial is right for you.