RecruitingPhase 1NCT05969041

Study of MT-302 in Adults With Advanced or Metastatic Epithelial Tumors

MYE Symphony: A Phase 1, Open-Label, First-in-Human, Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of MT-302 in Adults With Advanced or Metastatic Epithelial Tumors


Sponsor

Myeloid Therapeutics

Enrollment

48 participants

Start Date

Aug 2, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

MYE Symphony is a multicenter, open-label, Phase 1 first-in-human study to assess the safety, tolerability, and define the RP2D of MT-302 in participants with advanced epithelial cancer.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called MT-302 in adults with advanced or metastatic cancer (cancer that has spread or cannot be surgically removed). MT-302 is an experimental treatment being evaluated in a range of cancer types that have not responded to standard therapies. The study is primarily a Phase 1 trial, meaning it is focused on safety and finding the right dose. **You may be eligible if...** - You are 18 years or older - You have advanced or metastatic cancer of one of the following types: bladder, cervical, ovarian, triple-negative breast, hormone receptor-positive breast, pancreatic, stomach, esophageal, non-small cell lung, or colorectal cancer - Your cancer has progressed on or after standard treatments, or you have declined standard treatment - You are physically well enough to carry out normal daily activities (ECOG 0–1) - Your heart and organ function meets the required minimums - You have a life expectancy of more than 12 weeks **You may NOT be eligible if...** - Your cancer is not one of the listed types - You have significant heart problems or abnormal heart electrical activity - Your oxygen levels are below 90% on room air - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMT-302 (A)

MT-302 is an investigational drug


Locations(6)

St Vincent's Public Hospital Sydney

Darlinghurst, New South Wales, Australia

Scientia Clinical Research Ltd

Randwick, New South Wales, Australia

Westmead Hospital

Westmead, New South Wales, Australia

Souther Oncology Clinical Research Unit (SOCRU)

Bedford Park, South Australia, Australia

Cabrini Health

Malvern, Victoria, Australia

Linear Clinical Research Ltd

Nedlands, Western Australia, Australia

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05969041


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