NMDA Receptor Modulation for the Treatment of Bipolar I Disorder

This study is testing whether a drug that works on NMDA receptors (a brain chemical pathway) helps relieve depression in people with Bipolar I disorder. It is added on top of existing stable mood medications. **You may be eligible if...** - You are 18–65 years old - You have been diagnosed with Bipolar I disorder and are currently experiencing a depressive episode - You have been on a stable dose of an antipsychotic (quetiapine or lurasidone) and/or mood stabilizer for at least 4 weeks - Your depression is at least moderate in severity on a standard rating scale - Your manic symptoms are minimal **You may NOT be eligible if...** - You have a history of substance abuse in the past 6 months - You have epilepsy, a history of significant head trauma, stroke, or other serious neurological condition - You have a diagnosis of schizophrenia or another psychotic disorder - You have moderate-to-severe suicidal risk Talk to your doctor to see if this trial is right for you.