RecruitingPhase 1Phase 2NCT05985655

Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors

A Phase 1/2 Open-label Multicenter Study to Assess the Safety, Pharmacokinetics, and Anti-tumor Activity of GTAEXS617 in Patients With Advanced Solid Tumors


Sponsor

Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

Enrollment

230 participants

Start Date

Jul 6, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The primary purpose of this study is to assess the safety, tolerability, pharmacokinetics (PK) and anti-tumor activity of GTAEXS617 (REC-617) in participants with advanced solid tumors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new experimental drug called GTAEXS617 in people with advanced solid tumors — including head and neck cancer, pancreatic cancer, non-small cell lung cancer, and others — to see if it is safe and effective. **You may be eligible if...** - You have been diagnosed with a confirmed advanced solid tumor (such as head and neck, pancreatic, or lung cancer) - You are able to carry out basic daily activities with little or no assistance (ECOG 0-1) - Your expected survival is greater than 3 months **You may NOT be eligible if...** - You have poor physical function and cannot care for yourself - Your expected survival is 3 months or less - You have not been diagnosed with one of the specific tumor types in the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGGTAEXS617

Administered as specified in the treatment arm.

DRUGSoC

Participants will receive selected SoC regimen (fulvestrant, paclitaxel + bevacizumab, pegylated liposomal doxorubicin, or capecitabine) administered as specified in the treatment arm.


Locations(13)

USC Norris Comprehensive Cancer Center

Los Angeles, California, United States

START Midwest

Grand Rapids, Michigan, United States

START San Antonio

San Antonio, Texas, United States

START Mountain Region

West Valley City, Utah, United States

GZA Ziekenhuizen - Campus Sint-Augustinus

Antwerp, Belgium

Clinique Universitaires Saint-Luc

Brussels, Belgium

Institute Jules Bordet

Brussels, Belgium

CHU Sart Tilman

Liège, Belgium

The Beatson West of Scotland Cancer Centre

Glasgow, United Kingdom

UCL Hospitals NHS Foundation Trust

London, United Kingdom

The Christie NHS Foundation Trust

Manchester, United Kingdom

Newcastle Upon Tyne NHS Foundation Trust

Newcastle upon Tyne, United Kingdom

Oxford University Hospitals NHS Foundation Trust

Oxford, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT05985655


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