RecruitingNot ApplicableNCT05985993

Precise Intervention Technology and Application of Low Intensity TUS on Negative Symptoms of Schizophrenia

Precise Intervention Technology and Application of Low Intensity Transcranial Ultrasound Stimulation (TUS) on Negative Symptoms of Schizophrenia


Sponsor

Shanghai Mental Health Center

Enrollment

81 participants

Start Date

Dec 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Based on the current background and our previous studies, TUS has been proved that rTUS intervention could induce long-term potentiation like (LTP-like) plasticity and neuromodulate the brain cortex in schizophrenia patients. rTUS over the left dorsolateral prefrontal cortex (DLPFC) can alleviate the negative symptoms in schizophrenia. In this double-blind, randomized, sham-controlled study, the efficacy of different treatment options and mechanisms of low-intensity rTUS on negative symptoms will be investigated.


Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study uses low-intensity ultrasound waves applied to the brain (transcranial ultrasound stimulation) to treat the "negative symptoms" of schizophrenia — things like emotional flatness, lack of motivation, and social withdrawal — that medications often don't fully address. **You may be eligible if...** - You have a diagnosis of schizophrenia or schizoaffective disorder - You are between 18 and 50 years old and right-handed - You are currently on stable antipsychotic medication (second-generation) - You have noticeable negative symptoms such as emotional flatness or lack of motivation **You may NOT be eligible if...** - You do not have a schizophrenia spectrum diagnosis - You are left-handed - You have unstable symptoms or are not on a stable medication regimen Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICElow-intensity transcranial ultrasound stimulation (TUS)

The rTUS was administered using an immersion-type focused ultrasound transducer (V391-SU, Olympus NDT, Waltham, USA). Low-intensity transcranial ultrasound stimulation on the target. Duration:20 days (workdays for four consecutive weeks).


Locations(1)

Shanghai Mental Health Center

Shanghai, Shanghai Municipality, China

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NCT05985993


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