Evolution of PET Fixation With FDG at the End of Antibiotic Treatment of Infective Endocarditis on Valvular Prosthesis
Evolution of Positron Emission Computed Tomography (PET) Fixation With Fluorodeoxyglucose (FDG) at the End of Antibiotic Treatment of Infective Endocarditis on Valvular Prosthesis
Assistance Publique - Hôpitaux de Paris
50 participants
Apr 17, 2025
INTERVENTIONAL
Conditions
Summary
In patients with prosthetic valve endocarditis (PVE) and pathological valvular FDG uptake on the initial FDG-PET and not referred to valve replacement at the acute phase, the study will assess whether FDG-PET is able to identify those at increased risk of PVE relapse.
Eligibility
Inclusion Criteria5
- Patient aged 18 or over;
- Have a prosthetic valve implanted surgically or by catheter for at least 3 months;
- Presenting a definite IE on a prosthetic valve (ESC definition in force);
- Having benefited from an FDG-PET examination for diagnostic purposes as part of the treatment revealing pathological hyperuptake at the level of the prosthetic valve AND carried out \<15 days after the start of antibiotic therapy for infective endocarditis;
- Absence of cardiac surgical intervention performed for the current episode of AE or planned before the end-of-treatment FDG-PET
Exclusion Criteria5
- Patient under legal protection, guardianship or curators;
- Pregnancy, breastfeeding;
- Patient not affiliated to a health insurance scheme or not a beneficiary of a social security scheme;
- Simultaneous participation in a study on FDG-PET;
- Absence of informed consent signed by the patient."
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Interventions
FDG-PET at the end of treatment for IE in patients with a prosthetic valve
Locations(1)
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NCT05989152