Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion
Comprehensive Assessment of Tumor Stiffness and Adhesion in Glioma Using Magnetic Resonance Elastography: A Prospective Study
Shengjing Hospital
100 participants
Jan 1, 2017
INTERVENTIONAL
Conditions
Summary
this study will investigate the relationship between tumor stiffness and adhesion in gliomas using MRE. By utilizing preoperative MRE and Intraoperative neuronavigation, followed by comprehensive molecular pathology analysis, we aim to explore the correlation of tumor stiffness and adhesion with molecular and genetic characteristics of gliomas. Additionally, the predictive value of MRE in terms of pathological staging and prognosis will be determined. This research may pave the way for improved clinical decision-making, personalized treatment approaches, and more accurate clinical trials for glioma patients.
Eligibility
Inclusion Criteria5
- age older than 18 years
- Karnofsky performance status higher than 60
- with written informed consent
- MRE performed within one week before surgery
- tumor diameter > 2 cm
Exclusion Criteria5
- previous treatment for glioma
- inability to complete MRE due to intolerance (e.g., vibration-related discomfort or claustrophobia)
- completed MRE with suboptimal wave image quality (e.g., motion artifacts or inad-equate wave amplitude)
- failure to proceed with surgery after MRE
- missing IDH results
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Interventions
Undergo MRE and routine MRI
Undergo recording of tumor stiffness during surgery and molecular pathological classification through genetic analysis
Locations(1)
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NCT05990244