Sevoflurane General Anesthetic and Spatial Memory in Humans
Study of the Effect of Sevoflurane General Anesthetic on Spatial Memory in Humans
University of Chile
22 participants
Aug 14, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to learn about the effect of general anesthetic on spatial memory in adults who will undergo to an elective surgery. The main question it aims to answer is: • A surgical event under general anesthesia with sevoflurane transiently impairs spatial memory in humans and induces an increase in inflammatory cytokines. Participants will perform a virtual maze test and plasma samples will be taken before and after surgery.
Eligibility
Inclusion Criteria2
- Candidate for elective laparoscopic surgery of cholecystectomy.
- Age 30 to 50 years.
Exclusion Criteria5
- Visual or hearing difficulties.
- Malignant hyperthermia.
- Being treated with centrally acting drugs, such as anxiolytics, antidepressants, antipsychotics, anticonvulsants, anticholinergics, and first-generation antihistamines.
- Present a disorder of the sphere of neuropsychiatry
- Substance abuse disorder.
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Interventions
Adult patients between the ages of 30 and 50 who are to undergo elective surgery under general anesthesia will have their spatial memory tested and interleukin 1beta and alpha tumor necrosis measured before and after surgery.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT05991817