Randomized Study of Conditioning of Fludarabine Combined With Single or Dual Alkylating Agents in Myeloid Malignancies

This study is comparing two different chemotherapy preparation regimens (called conditioning) before a bone marrow transplant for people with blood cancers. The goal is to find the best approach to prepare the body for the transplant and reduce relapse. **You may be eligible if...** - You have acute myeloid leukemia (AML) in your first complete remission, or myelodysplastic syndrome (a pre-leukemia bone marrow disorder) with a certain level of abnormal cells - You have a matched bone marrow donor (related, unrelated, or half-matched) - You have provided informed consent **You may NOT be eligible if...** - Your AML has spread to the brain or other areas outside the bone marrow - You currently have an active serious infection (viral, bacterial, or fungal) - You have a specific AML type called acute promyelocytic leukemia Talk to your doctor to see if this trial is right for you.