RecruitingNot ApplicableNCT05997030

Low-Intensity Focused Ultrasound (LIFU) Neuromodulation

Early Feasibility Study of Low-Intensity Focused Ultrasound (LIFU) Neuromodulation in Patients With Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease

Sponsor

Ali Rezai

Enrollment

15 participants

Start Date

Oct 12, 2023

Study Type

INTERVENTIONAL

Conditions

Alzheimer Disease

Summary

This study is a prospective, single-center, single-arm early feasibility study, to establish safety and tolerability of LIFU for neuromodulation in patients with mild cognitive impairment ( MCI) due to Alzheimer's disease.

Eligibility

Min Age: 45 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing low-intensity focused ultrasound (LIFU) — a non-invasive brain stimulation technique using targeted sound waves — to see if it can slow cognitive decline in people with mild cognitive impairment (MCI) due to Alzheimer's disease. **You may be eligible if...** - You are between 45 and 85 years old - You have been diagnosed with mild cognitive impairment (MCI) due to Alzheimer's disease - If you take Alzheimer's medications (AChEI or memantine), you have been on a stable dose for at least 45 days - You are able to communicate and describe sensations during the procedure **You may NOT be eligible if...** - You have a pacemaker, metal implants, cochlear implants, or other devices that prevent an MRI - You have severe dementia (not mild cognitive impairment) - You are unable to undergo MRI safely Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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