Oral, Chemosensory and Trigeminal Functions in Allo-HSCT
Oral, Chemosensory and Trigeminal Functions in Allogeneic Hematopoietic Stem Cell Transplantation - a Prospective Cohort-study
University of Oslo
70 participants
Aug 10, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this prospective, cohort study is to learn about smell, taste and trigeminal dysfunction in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The research team hypothesizes that treatment with allo-HSCT will induce: * Distortion of taste and smell and trigeminal functions like cooling, tingling, and burning sensations. * Reduced saliva production leading to oral dryness and dental caries. * Changes in the connectivity of the taste-, smell- and pain-cortical brain regions.
Eligibility
Inclusion Criteria1
- patients receiving myeloablative conditioning for a first-time allo-HSCT and diagnosed with either a leukemia or a myelodysplastic syndrome
Exclusion Criteria4
- disorders affecting the oral cavity including poor tooth-status
- those using drugs affecting the gustatory/olfactory functions
- those with brain disorders
- those who have a chronic disorder affecting the immune system, have cancer or who are pregnant.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06003660