Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer

This study is testing a personalized, adaptive approach to treating advanced head and neck cancer (HPV-negative) with radiation and chemotherapy — adjusting the treatment plan based on how the tumor responds during therapy. **You may be eligible if:** - You are 18 or older - You have been diagnosed with locally advanced head and neck cancer (stage III or IV) that is HPV-negative - Your cancer is in the oral cavity, throat, voice box, nasal sinuses, or nearby areas - You have not previously had radiation or chemotherapy for head and neck cancer - Your organs (blood, kidney, liver) are working well enough to tolerate treatment **You may NOT be eligible if:** - Your cancer has spread to distant parts of the body - You have HIV, active hepatitis B/C, or active tuberculosis - You have received other immune-suppressing treatments recently - You are pregnant or breastfeeding - You received a live vaccine within 28 days Talk to your doctor to see if this trial is right for you.