CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
The Application of Anesthesia Depth Monitoring on Post-operative Cognitive Dysfunction for Patients With Hydrocephalus Receiving Ventricular-peritoneal Shunt Surgery and Associated Change in CSF Metabolomics and Glymphatic Function.
Chang Gung Memorial Hospital
48 participants
Jul 1, 2023
INTERVENTIONAL
Conditions
Summary
In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with normal pressure hydrocephalus for VP shunt surgery. The investigators assume that the use of dexmedetomidine infusion and proper anesthsia depth during general anesthesia, in addition to multi-model analgesia, might be helpful to enhance glymphatic function, reduce neuroinflammation, and decrease postoperative cognitive dysfunction.
Eligibility
Inclusion Criteria5
- patients with communicating hydrocephalus for elective VP shunt surgery under general anesthesia
- age> 60 y/o
- conscious clear
- fluency in Chinese
- anticipated hospital stay ≥ 3 days after surgery
Exclusion Criteria7
- unstable preoperative condition (unstable angina, CHF, asthma attack) within 4 weeks before surgery,
- severe hepatic dysfunction or renal failure
- history of neuropsychological diseases such as schizophrenia, Parkinson's disease, dementia, stroke,
- pre-op cognitive impairment,
- preoperative delirium,
- preoperative depression,
- allergy to contrast medium of MRI.
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Interventions
dexmedetomidine infusion
intraoperative anesthesia depth monitoring to keep BIS 40-60
Locations(1)
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NCT06005363