RecruitingNot ApplicableNCT06005363

CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.

The Application of Anesthesia Depth Monitoring on Post-operative Cognitive Dysfunction for Patients With Hydrocephalus Receiving Ventricular-peritoneal Shunt Surgery and Associated Change in CSF Metabolomics and Glymphatic Function.

Sponsor

Chang Gung Memorial Hospital

Enrollment

48 participants

Start Date

Jul 1, 2023

Study Type

INTERVENTIONAL

Conditions

The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and Neuroinflammation The Association of Postoperative Cognitive Dysfunction With CSF Metabolomic Change

Summary

In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with normal pressure hydrocephalus for VP shunt surgery. The investigators assume that the use of dexmedetomidine infusion and proper anesthsia depth during general anesthesia, in addition to multi-model analgesia, might be helpful to enhance glymphatic function, reduce neuroinflammation, and decrease postoperative cognitive dysfunction.

Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Dexmedetomidine and a medical device called anesthesia depth monitoring for people with the association of postoperative cognitive dysfunction with csf metabolomic change and the association of postoperative cognitive dysfunction with glymphatic function and neuroinflammation. The study is currently recruiting participants at 1 location. People eligible for this study include aged 60 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDexmedetomidine

dexmedetomidine infusion

DEVICEanesthesia depth monitoring

intraoperative anesthesia depth monitoring to keep BIS 40-60

Locations(1)

Linkou Chang Gung Memorial Hospital

Taoyuan, Taiwan

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NCT06005363