RecruitingPhase 1NCT06006741

Universal CAR-T Cells Targeting Multiple Myeloma

Universal CAR-T Cells for the Treatment of Multiple Myeloma


Sponsor

Shenzhen Geno-Immune Medical Institute

Enrollment

20 participants

Start Date

Oct 31, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this study is to assess the feasibility, safety and efficacy of universal CAR T cells targeting multiple myeloma. Another goal of the study is to learn more about the persistence and function of the universal CAR T cells in the body.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of CAR-T cell therapy (using donor immune cells, not the patient's own) that targets multiple myeloma — a blood cancer — in patients whose disease has returned or not responded to previous treatments. **You may be eligible if:** - You have multiple myeloma that has not achieved complete remission after at least 2 treatment regimens - You have high-risk myeloma and are not eligible for a stem cell transplant due to age or other health issues - You have relapsed after a prior stem cell transplant and have some remaining cancer - You have adequate vein access for the cell collection process **You may NOT be eligible if:** - You are pregnant or nursing - You have an uncontrolled active infection - You have active hepatitis B, hepatitis C, or HIV - You are currently on systemic steroid medications - You have previously received CAR-T cell therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALMM-specific universal CAR T cells

Infusion of MM-specific universal CAR T cells


Locations(1)

Shenzhen Geno-Immune Medical Institute

Shenzhen, Guangdong, China

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NCT06006741