RecruitingNot ApplicableNCT06007950

Time-restricted Eating Study (TRES): Impacts on Anthropometric, Cardiometabolic and Cardiovascular Health

Impacts of Time-Restricted Eating on Weight, Cardiometabolic and Cardiovascular Health in Patients With Acute Coronary Syndrome

Sponsor

Universiti Teknologi Mara

Enrollment

48 participants

Start Date

Sep 1, 2023

Study Type

INTERVENTIONAL

Conditions

Myocardial Infarction

Summary

The goal of this clinical trial is to learn about the effects of time-restricted eating in patients with history of acute coronary syndrome. The main questions it aims to answer are: 1) Is 10-hr TRE safe and feasible for patients with ACS; 2)What are the impacts of 10-hr TRE on anthropometric measurements, cardiometabolic health and cardiovascular health compared to ad libitum eating in patients with ACS?. Participants will be asked to limit eating duration to 10 hours daily.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria4

Adult, 18- 65 years old.
Had history of acute coronary syndrome (ACS)
Clinically stable
Self-reported eating window of at least 12 h per day.

Exclusion Criteria17

Severe obesity (body mass index ≥40 kg m-2).
Unstable weight in the past three months (gain or lose more than 4 kg of weight).
Unstable cardiovascular, renal, cardiac, liver, lung, adrenal, or nervous system disease that may compromise study validity.
Any medications or supplements known to change sleep, circadian rhythms, or metabolism.
Pregnant or lactating women.
Perform overnight shift work more than one day/week on average.
Regularly fasted for more than 15 hours/day or having completed twelve 24-hr fasts within the past three months).
Active use of tobacco or illicit drug or history of treatment for alcohol abuse.
Type I diabetes or diabetic, treated with insulin.
Use of anti-obesity drugs or other drugs affecting body weight.
Currently enrolled in weight loss or management programme, including surgical intervention.
Severe kidney failure (glomerular filtration rate (GFR) <30 mL/min).
Eating disorder or current diagnosis of uncontrolled psychiatric illness, which may impair study involvement.
Malignancy undergoing active treatment.
Had gastrointestinal surgery or impaired nutrient absorption.
Travelled more than two time zones away two months prior to enrolling in the trial or will travel more than two time zones away during the study period.
Concurrent participation in other interventional studies

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Interventions

BEHAVIORALTime-restricted eating 10-hr

Time-restricted eating is a form of intermittent fasting. In this study, 10-hr TRE will be employed, where eating duration is limited to 10 hours. Participants are allowed to consume non-caloric beverages during fasting period.