RecruitingPhase 4NCT06013956

Personalized Real-Time DBS and PD Mechanisms

Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinson's Disease Using Real-Time Neural Control

Sponsor

David Escobar

Enrollment

25 participants

Start Date

Aug 29, 2023

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS) implantation surgery for the treatment of Parkinson's disease as per standard of care will be invited to participate in this study. This mechanistic study is aimed at better understanding the role of basal ganglia beta band (11-35 Hz) oscillations and resonance in the manifestation of Parkinson's disease (PD) motor signs using closed-loop electrical neurostimulation, levodopa medication, and computational modeling. The ultimate goal of this study is to inform the development of closed-loop neuromodulation technology that can be programmed and adjusted in real time based on patient-specific neural activity.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This research study is investigating deep brain stimulation (DBS) — a surgical treatment for Parkinson's disease — with a focus on personalizing how the stimulation is delivered in real-time based on brain signals. The goal is to better understand how DBS works and improve it for patients. **You may be eligible if...** - You have been diagnosed with idiopathic (classic) Parkinson's disease - Your doctor has already determined you are a candidate for DBS surgery targeting the subthalamic nucleus as part of your standard care - You are able to tolerate brief delays in taking your Parkinson's medications - You can provide informed consent **You may NOT be eligible if...** - Your Parkinsonism is caused by a stroke, another brain disease, or a secondary cause - You have a condition that would significantly increase the risk of the study procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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