RecruitingNot ApplicableNCT06014034

Randomized Controlled Study of Programmed Weaning From NIV for AECOPD

Randomized Controlled Study of Programmed Weaning From Noninvasive Mechanical Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Sponsor

Peking University Third Hospital

Enrollment

50 participants

Start Date

May 12, 2023

Study Type

INTERVENTIONAL

Conditions

Acute Exacerbation of COPD

Summary

Purpose of research:to explore a reasonable programmed withdrawal process of noninvasive ventilation and thereby reduce the duration of noninvasive mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a structured, programmed approach to weaning patients off non-invasive ventilation (a breathing support mask, not a breathing tube) during an acute flare-up of COPD (chronic obstructive pulmonary disease), compared to the usual approach. **You may be eligible if...** - You are 40 or older - You have been admitted with an acute COPD flare-up - Your blood gases show respiratory acidosis (your blood is too acidic from CO2 buildup), with a pH between 7.20 and 7.35 - You are already on and tolerating non-invasive ventilation (NIV, a breathing mask) **You may NOT be eligible if...** - You are under 40 - You are pregnant - You have HIV - Your blood pressure or circulation is unstable (hemodynamic instability) - You or your family refuse intubation or resuscitation if needed Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERProgrammed Weaning From Noninvasive Mechanical Ventilation

Programmed withdrawal unit: daily morning review arterial blood gas analysis (since the 2nd, daily morning stop non-invasive ventilation 1 hours, 2 hours, 3 hours, 4 hours after check arterial blood gas analysis), blood gas results suggest respiratory acidosis compensatory period (pH value greater than 7.35) can reduce daily noninvasive ventilation time, namely the noninvasive ventilation use time for 24 hours, 20 hours, the third day 16 hours, the fourth 12 hours, fifth day 8 hours. If ABG indicates still acid decompensation, continue the non-invasive ventilation regimen of the previous day. If noninvasive ventilation failed, invasive mechanical ventilation was performed.