Randomized Controlled Study of Programmed Weaning From NIV for AECOPD
Randomized Controlled Study of Programmed Weaning From Noninvasive Mechanical Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Peking University Third Hospital
50 participants
May 12, 2023
INTERVENTIONAL
Conditions
Summary
Purpose of research:to explore a reasonable programmed withdrawal process of noninvasive ventilation and thereby reduce the duration of noninvasive mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease.
Eligibility
Inclusion Criteria2
- It is defined that in patients with acute exacerbation of chronic obstructive pulmonary disease, the arterial blood gas analysis was decompensation of respiratory acidosis, and the pH value was 7.20-7.35
- Non-invasive mechanical ventilation was performed and it was well tolerated
Exclusion Criteria5
- younger than 40 years old
- pregnancy
- Human immunodeficiency virus (HIV) antibody was positive
- Hemodynamic instability
- Mechanical ventilation for endotracheal intubation and cardiopulmonary resuscitation were disagreed
Interventions
Programmed withdrawal unit: daily morning review arterial blood gas analysis (since the 2nd, daily morning stop non-invasive ventilation 1 hours, 2 hours, 3 hours, 4 hours after check arterial blood gas analysis), blood gas results suggest respiratory acidosis compensatory period (pH value greater than 7.35) can reduce daily noninvasive ventilation time, namely the noninvasive ventilation use time for 24 hours, 20 hours, the third day 16 hours, the fourth 12 hours, fifth day 8 hours. If ABG indicates still acid decompensation, continue the non-invasive ventilation regimen of the previous day. If noninvasive ventilation failed, invasive mechanical ventilation was performed.
Locations(1)
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NCT06014034