An Imaging Study of Polyvascular Disease
Early Screen, Systematic Evaluation and Risk Warning of Polyvascular Disease Based on Multi-modality Imaging
Harbin Medical University
1,100 participants
Oct 18, 2023
OBSERVATIONAL
Conditions
Summary
1. Establish a multimodality imaging database for PVD, improve the one-stop screening process for early PVD based on artificial intelligence, build a full-cycle control information platform, and promote the construction and standardization of a multidisciplinary co-morbidity and co-management diagnosis and treatment model. 2. Based on non-invasive, zero-contrast ocular OCTA combined with one-stop CTA imaging of the heart and brain, construct an integrated "eye-heart-brain" early warning model for PVD, and explore a potential non-invasive and convenient early warning system for PVD. 3. Based on the multi-omics, investigate EVs-mediated intercellular communication network, elucidate the roles and regulatory mechanisms of EVs in the development of PVD, search for potential targets for intervention, and construct an artificial intelligence-based "pan-vascular score" risk assessment system based on the combination of multi-modality imaging and multi-omics biomarkers.
Eligibility
Inclusion Criteria9
- Task 1:
- Patients with coronary artery disease (≥50% stenosis in any coronary artery on coronary angiography)
- Age ≥18 years old
- Proposed OCT-IVUS integrated imaging system
- able to provide written informed consent prior to the start of any procedures related to the study.
- Task 2:
- patients with coronary artery disease (coronary angiography reveals ≥50% degree of stenosis in any coronary artery) and patients with stroke or TIA (confirmed by a neurologist)
- Age ≥ 18 years
- able to provide written informed consent prior to the start of any procedures related to the study.
Exclusion Criteria27
- Task 1:
- severely tortuous/calcified coronary arteries with anticipated difficulty in completing the OCT-IVUS integrated imaging system
- uncontrolled congestive heart failure or acute left heart failure;plan
- claustrophobia;
- left main stem occlusion;
- proposed coronary artery bypass grafting (CABG);
- uncontrolled severe ventricular arrhythmia;
- active bleeding or severe bleeding tendency;
- acute stroke;
- patients with hemodynamic instability or unstable cardiac electrical activity (including shock) ;
- severe renal insufficiency and/or anuria, except in cases where dialysis treatment has been planned;
- contraindications to the application of contrast media;
- patients who are severely uncooperative due to psychiatric or serious systemic illness;
- Patients who, in the opinion of the investigator, are unsuitable for participation in the study.
- Task 2:
- patients who are unable to comply with the follow-up schedule;
- uncontrolled congestive heart failure or acute left heart failure;
- patients with a life expectancy of less than 6 months;
- left main stem occlusion;
- proposed coronary artery bypass grafting (CABG);
- uncontrolled severe ventricular arrhythmia;
- active bleeding or severe bleeding tendency;
- patients with hemodynamic instability or unstable cardiac electrical activity (including shock) ;
- severe renal insufficiency and/or anuria, except in cases where dialysis treatment has been planned;
- contraindications to the application of contrast media;
- patients who are severely uncooperative due to psychiatric or serious systemic illness;
- patients who, in the opinion of the investigator, are not suitable for participation in the study.
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Interventions
Magnetic Resonance Angiography of intracranial artery, carotid artery, renal artery and lower extremity artery, CT angiography of coronary artery or intracranial artery
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06016608