Thalidomide to Chemotherapy Related Nausea and Vomiting in Pancreatic Cancer

This trial tests whether thalidomide (a medication with anti-nausea properties) can reduce severe nausea and vomiting caused by chemotherapy in patients with metastatic pancreatic cancer. **You may be eligible if...** - You are between 18 and 80 years old - You have confirmed metastatic pancreatic cancer (adenocarcinoma) - You have not yet received any anti-cancer treatment - Your organs are functioning well enough (based on blood tests) - You are functioning reasonably well in daily life (ECOG 0–2) - You agree to use contraception during the study **You may NOT be eligible if...** - You have already received any cancer treatment - Your pancreatic cancer is not adenocarcinoma - You are pregnant or breastfeeding - You have active gut inflammation (pancreatitis, cholecystitis, etc.) - You have uncontrolled diabetes, high blood pressure, serious heart disease, or recent stroke - You are allergic to gemcitabine or nab-paclitaxel Talk to your doctor to see if this trial is right for you.