De-Intensification of Postoperative Radiotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck

This study is looking at whether reducing the intensity of radiation therapy after surgery for head and neck squamous cell cancer (a type of cancer affecting the mouth, throat, or voice box) is as safe and effective as standard radiation. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with squamous cell carcinoma of the mouth, throat, or voice box (certain locations) - You have had surgery to remove the tumor and lymph nodes - You have no cancer spread to distant organs - You are in good enough health to receive radiation therapy (ECOG score 0–2) - Radiation is planned to start at least 6 weeks after your surgery **You may NOT be eligible if...** - The cancer was not completely removed during surgery - The cancer has spread to distant parts of the body - You have cancer coming back after surgery (early recurrence) - You are pregnant or breastfeeding - You had radiation to the head and neck area before, or prior chemotherapy/immunotherapy Talk to your doctor to see if this trial is right for you.