RecruitingNCT06036641

The Effects of Prolonged Head-Down Tilt Lithotomy Position on Lower Limb Haemodynamics

The Effects of Prolonged Head-Down Tilt Lithotomy Position on Lower Limb Haemodynamics in Adults Undergoing Minimally Invasive Abdominopelvic Surgery: An Intraoperative Observational Study


Sponsor

University of Portsmouth

Enrollment

25 participants

Start Date

Jul 22, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

During certain bowel surgeries for cancer (colorectal surgery), individuals frequently have to be placed in a head-down position to enable surgeons have optimal access to the cancer site. This position usually also involves bending the hips and knees while supporting the legs in stirrups. However, lying in this position for long periods of time can lower the flow of blood to the legs, which can potentially cause injury. This rare but severe consequence is called Well-Leg Compartment Syndrome (WLCS). If WLCS is not diagnosed quickly, it can lead to other difficult complications and a significant delay in recovery. Unfortunately, because the individual is under anaesthesia, diagnosis is delayed in many cases. There is very little information in the medical literature about how this damage to the legs progresses over the course of the surgery. To better understand how WLCS, how well blood vessels work during surgery will be assessed. The flow of blood and oxygen in the calf muscle will be assessed in 25 individuals placed in a head-down position during colorectal surgery. Likewise, blood samples will be obtained in order to measure the biological markers that may contribute to the development of WLCS.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Adults scheduled to undergo colorectal surgery in the HDTL position

Exclusion Criteria5

  • History of myocardial infarction or cerebro-vascular events in the last 12 months
  • Previous revascularisation procedure in their lower limbs
  • BMI > 40 kg/m2
  • Inability to give informed consent
  • Other serious medical conditions, which in the opinion of study investigators, would interfere with safety or data interpretation

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Interventions

DEVICENIRS monitoring

All participants will undergo NIRS monitoring of muscle and cerebral tissue oxygenation intraoperatively.

DEVICELaser Doppler flowmetry

Cutaneous blood flow will be assessed intraoperatively via Laser Doppler flowmetry in all participants

OTHERInflammatory and Oxidative stress biomarkers

Blood samples will be taken to measure biomarkers of inflammation and oxidative stress at specific time points


Locations(1)

Queen Alexandra Hospital, Portsmouth Hospitals University NHS Trust

Portsmouth, West Sussex, United Kingdom

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NCT06036641